Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
نویسندگان
چکیده
منابع مشابه
Coding mutations in SORL1 and Alzheimer disease.
OBJECTIVE Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established. The study was undertaken to identify functional SORL1 mutations in patients with LOAD. METHODS This was a family- and cohort-based genetic association study. Caribbean His...
متن کاملPossible Association between SORL1 and Alzheimer Disease?
However, using a model restricted to elderly APOE 4 noncarriers, the association became somewhat stronger (SNP 8, p = 0.0163; SNP 24, p = 0.0375). More importantly, the associated variants in the study by Shibata et al. [1] were identical to those in the study by Rogaeva et al. [2] . For SNP 24, the T allele was associated with AD in Caucasians as well as in Japanese people. For SNP 8, the C al...
متن کاملEffect of Memantine on Expression of NAT-Rad18, Rad18 and Sorl1 Genes in Rat Model of Alzheimer\'s Disease
Background and Objective: Dysregulation of long-term expression of non-coding RNAs (lncRNAs) has a potential role in progressive brain disorders such as Alzheimer's disease. This study aimed to analyze the apoptosis and expression of 51A and NAT-Rad18 lncRNAs and their target genes in brain tissue and peripheral blood mononuclear cells (PBMCs) of the rat model of AD, before and after memantine ...
متن کاملAssociations of sorLA/SORL1 with Alzheimer's disease
In recent years Alzheimer’s disease (AD) has emerged as a research priority mainly due to an impressive increase in the average life expectancy in humans, which is associated with debilitating neurodegenerative disorders. The cardinal feature of the disease is accumulation of the amyloid-β peptide, which is derived from the sequential proteolytic cleavage of the amyloid precursor protein (APP)....
متن کاملIdentification of Alzheimer disease risk genotype that predicts efficiency of SORL1 expression in the brain.
OBJECTIVE To identify SORL1 risk genotypes that determine receptor protein expression in the human brain. DESIGN DNA, RNA, and proteins were extracted from brain autopsies of Alzheimer disease cases and used for SORL1 genotyping, RNA profiling, and SORLA protein quantification, respectively. SETTING Specimens were provided by the MRC London Brain Bank for Neurodegenerative Diseases and the ...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2009
ISSN: 1750-1326
DOI: 10.1186/1750-1326-4-46